Tag Archives: socialability

We have just published our first paper on extending the rodent model of maternal immune activation to monkeys. As repeat readers of this blog, and the accompanying book, well know, an important risk factor for both autism and schizophrenia is … Continue reading

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Pure cure for autism?

An impressive new paper is just out from Robert Naviaux, Susan Powell and colleagues at UC San Diego. They use our mouse model of the autism and schizophrenia risk factor, maternal immune activation during pregnancy, to show that a drug … Continue reading

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Why wasn’t major depressive disorder eliminated during evolution?

My posts have overwhelmingly focused on autism and schizophrenia, but my book also covers links between immune factors and major depressive disorder (MDD). However, an email from science writer Virginia Hughes stimulates me to write about MDD here. Ginny reminded … Continue reading

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Advances presented at the recent Society for Neuroscience meeting

After 5 intensive days at the annual meeting held this year in New Orleans, things are just getting back to normal around here. Among the >28,000 participants, there were several presentations that particularly caught my eye in the areas of … Continue reading

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Gastrointestinal and microbiome changes in autism?

Tony Persico and V. Napolioni have just published a review article centered around their finding that a particular molecule, p-cresol, is excreted (found in the urine) at higher levels in autistic kids than in controls. I described their initial finding … Continue reading

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Anti-inflammatory treatments for autism

With the publication of our new paper (see the prior post), folks have asked, since bone marrow transplant (BMT) ameliorates several of the autism-like behaviors in our mouse model of maternal infection, are we saying that such transplants should be … Continue reading

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Cluster analysis of symptoms identifies a very significant “immune group” in autism patients

The heterogeneity of symptoms among patients with¬†autism spectrum disorder (ASD) is a major problem for researchers working on the etiology and pathology of the disorder. This diversity also poses a significant hurdle in evaluating the efficacy of potential therapies. Various … Continue reading

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“Fragile” hope for autism

In chapter 9 (“Reasons for Optimism”) of my book I discuss startling results obtained with various mouse models of genetic disorders that display some autism symptoms. That is, in mice carrying the fragile X syndrome (FXS), Rett syndrome or tuberous … Continue reading

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Visual map coding nature versus nurture across England

O.S.P. Davis and colleagues at King’s College, London just published a provocative paper that aims to plot on a map of England the geographic distribution of the relative contributions of genetics and environment to 45 different childhood cognitive and behavioral … Continue reading

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Mouse model of an autism risk factor displays the cardinal symptoms of the disorder

Our group has just published on line¬†new results on a mouse model of the maternal infection risk factor for autism. In this model, pregnant mice are given an immune activation to imitate an infection such as the flu. The new … Continue reading

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